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MT1 (Melanotan‑1) is a 13‑amino‑acid synthetic analog of endogenous α‑melanocyte‑stimulating hormone (α‑MSH), with key structural modifications (Met⁴→Nle, Phe⁷→D‑Phe) that enhance receptor affinity and enzymatic stability. It acts as a potent agonist for melanocortin‑1 receptor (MC1R), and also targets MC3R/MC4R/MC5R; upon binding, it elevates intracellular cAMP, activates MITF, and boosts eumelanin synthesis in melanocytes, providing UV‑protective skin pigmentation. Beyond tanning, MT1 reduces phototoxicity in erythropoietic protoporphyria, shows anti‑inflammatory, antioxidant, and metabolic benefits (enhancing fat oxidation), and is studied for polymorphous light eruption and actinic keratosis. It is typically administered subcutaneously at 0.5–1 mg daily, with mild side effects like nausea and appetite suppression.
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